Hai-Hui (Howard) Xue, M.D., Ph.D., is a member of the Center for Discovery and Innovation.
Dr. Xue’s lab investigates transcriptional and epigenetic regulation of T cell development in the thymus, T cell activation and differentiation in response to pathogen infection and in tumor microenvironment. The Xue lab is also interested in intrinsic regulators of self-renewal of hematopoietic and leukemic stem cells. For key biological processes, they focus on cell fate specification, cell identity commitment, and functional plasticity. For key molecular processes, they emphasize intra-molecule structure-function delineation, regulatory complex fluidity, and dynamic network programming within specific cell context, and aim to extract core regulatory concepts conserved across different cell contexts. The Xue lab integrates genome-wide profiling of histone modification, chromatin accessibility and interactions with mouse genetics and comprehensive functional characterization to precisely connect molecule events with functional output. Their long-term goal is to harness molecular insights in immune cells to improve treatment of emerging infectious diseases and tumors.
Xue Lab: Publications
Shan Q, Li X, Chen X, Zeng Z, Zhu S, Gai K, Peng W, Xue HH. Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture. Nat Commun. 2021 Oct 6;12(1):5863. doi: 10.1038/s41467-021-26159-1. PMID: 34615872; PMCID: PMC8494933.
Zhao X, Shan Q, Xue HH. TCF1 in T cell immunity: a broadened frontier. Nat Rev Immunol. 2021 Jun 14. doi: 10.1038/s41577-021-00563-6. Epub ahead of print. PMID: 34127847.
Shan Q, Hu S, Chen X, Danahy DB, Badovinac VP, Zang C, Xue HH. Ectopic Tcf1 expression instills a stem-like program in exhausted CD8+ T cells to enhance viral and tumor immunity. Cell Mol Immunol. 2021 May;18(5):1262-1277. doi: 10.1038/s41423-020-0436-5. Epub 2020 Apr 27. PMID: 32341523; PMCID: PMC8093427.
Li F, Zhao X, Zhang Y, Shao P, Ma X, Paradee WJ, Liu C, Wang J, Xue HH. TFH cells depend on Tcf1-intrinsic HDAC activity to suppress CTLA4 and guard B-cell help function. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2014562118. doi: 10.1073/pnas.2014562118. PMID: 33372138; PMCID: PMC7812797.
Zhao X, Shao P, Gai K, Li F, Shan Q, Xue HH. β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells. Elife. 2020 Aug 21;9:e55360. doi: 10.7554/eLife.55360. PMID: 32820720; PMCID: PMC7462606.