Liang Chen, Ph.D.   

Chen Lab

Liang Chen, Ph.D. is an Associate Member of the Center for Discovery and Innovation (CDI) and an Associate Professor at the Hackensack Meridian School of Medicine.

Dr. Chen studies the molecular epidemiology of antimicrobial resistance and infectious disease, with particular focus on Multidrug resistant Gram-negative bacteria (MDRGN), Methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant mycobacteria. Dr. Chen has authored over 150 peer-reviewed publications and had > 60 posters/oral presentations on international and/or national conferences. He uses genomic sequencing together with informatics tools and clinical epidemiology to tackle the menace of emerging bacterial resistance.

Currently, Dr. Chen is seeking to decipher the molecular evolution of carbapenem-resistant Enterobacteriaceae (CRE). CRE have been described as “nightmare bacteria”, and been classified as an “urgent threat” by CDC. CRE have increased over the past decade and grown resistance to even the most powerful antibiotics. The worldwide dissemination of CRE is predominately associated with a major Klebsiella pneumoniae clone, ST258. Using the whole genomic analysis, Dr. Chen and his colleagues have revealed that the ST258 is a hybrid strain that originated as a large chromosomal recombination (Fig1). Meanwhile, this superclone is under significantly diversification, primarily due to the recombination of antigen encoded capsular polysaccharide synthesis (cps) region and plasmid acquisition.

A major concern about CRE is that resistance targets are primarily carried on plasmids that can easily transfer the resistance to other bacteria. Another aspect of Dr. Chen’s work is to develop robust molecular detection platforms to track the dissemination of the life-threatening bacteria, and more importantly, to explore CRE transmission from the traditional “strain epidemiology” to “plasmid epidemiology”. Using WGS technique and comparative genomic analysis, Dr. Chen has identified and characterized the epidemic drug-resistant plasmids prevailing in the epicenter of this epidemic (NY/NJ) and developed molecular tools to rapidly track the spread of these resistance plasmids. Meanwhile, he has also been devoted to investigating other mobile genetic elements (MGE)-mediated mechanisms, such as plasmid-encoded colistin and tigecycline resistance in Enterobacteriaceae, and plasmid-mediated hypervirulence in K. pneumoniae.

Molecular evolution of carbapenem resistant K. pneumoniae ST258
The molecular evolution of carbapenem resistant K. pneumoniae ST258

Publications in recent 3 years:

  1. Zhang X, Wang W, Yu H, Wang M, Zhang H, Lv J, Tang YW, Kreiswirth BN, Du H, Chen LNew Delhi Metallo-β-Lactamase 5-Producing Klebsiella pneumoniae Sequence Type 258, Southwest China, 2017. Emerg Infect Dis. 2019 Jun;25(6):1209-1213. doi: 10.3201/eid2506.181939. PubMed PMID: 31107227.
  2. Papp-Wallace KM, Zeiser ET, Becka SA, Park S, Wilson BM, Winkler ML, D’Souza R, Singh I, Sutton G, Fouts DE, Chen L, Kreiswirth BN, Ellis-Grosse EJ, Drusano GL, Perlin DS, Bonomo RA. Ceftazidime-Avibactam in Combination With Fosfomycin: A Novel Therapeutic Strategy Against Multidrug-Resistant Pseudomonas aeruginosa. J Infect Dis. 2019 May 17;. doi: 10.1093/infdis/jiz149. [Epub ahead of print] PubMed PMID: 31099835.
  3. Evans SR, Tran TTT, Hujer AM, Hill CB, Hujer KM, Mediavilla JR, Manca C, Domitrovic TN, Perez F, Farmer M, Pitzer KM, Wilson BM, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Fowler VG, Chambers HF, Bonomo RA. Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam Against Pseudomonas aeruginosa: PRIMERS IV. Clin Infect Dis. 2019 May 17;68(11):1823-1830. doi: 10.1093/cid/ciy801. PubMed PMID: 30239599.
  4. Lowe M, Kock MM, Coetzee J, Hoosien E, Peirano G, Strydom KA, Ehlers MM, Mbelle NM, Shashkina E, Haslam DB, Dhawan P, Donnelly RJ, Chen L, Kreiswirth BN, Pitout JDD. Klebsiella pneumoniae ST307 with blaOXA-181, South Africa, 2014-2016. Emerg Infect Dis. 2019 Apr;25(4):739-747. doi: 10.3201/eid2504.181482. PubMed PMID: 30882333; PubMed Central PMCID: PMC6433043.
  5. Jung HJ, Littmann ER, Seok R, Leiner IM, Taur Y, Peled J, van den Brink M, Ling L, Chen L, Kreiswirth BN, Goodman AL, Pamer EG. Genome-Wide Screening for Enteric Colonization Factors in Carbapenem-Resistant ST258 Klebsiella pneumoniae. MBio. 2019 Mar 12;10(2). doi: 10.1128/mBio.02663-18. PubMed PMID: 30862751; PubMed Central PMCID: PMC6414703.
  6. Meng X, Yang J, Duan J, Liu S, Huang X, Wen X, Huang X, Fu C, Li J, Dou Q, Liu Y, Wang J, Yan Q, Zou M, Liu W, Peng Z, Chen L, Li C, Wu A. Assessing Molecular Epidemiology of Carbapenem-resistant Klebsiella pneumoniae (CR-KP) with MLST and MALDI-TOF in Central China. Sci Rep. 2019 Feb 19;9(1):2271. doi: 10.1038/s41598-018-38295-8. PubMed PMID: 30783127; PubMed Central PMCID: PMC6381170.
  7. Pandey R, Chen L, Manca C, Jenkins S, Glaser L, Vinnard C, Stone G, Lee J, Mathema B, Nuermberger EL, Bonomo RA, Kreiswirth BN. Dual β-Lactam Combinations Highly Active against Mycobacterium abscessus Complex In VitroMBio. 2019 Feb 12;10(1). doi: 10.1128/mBio.02895-18. PubMed PMID: 30755518; PubMed Central PMCID: PMC6372805.
  8. Miao M, Wen H, Xu P, Niu S, Lv J, Xie X, Mediavilla JR, Tang YW, Kreiswirth BN, Zhang X, Zhang H, Du H, Chen LGenetic Diversity of Carbapenem-Resistant Enterobacteriaceae (CRE) Clinical Isolates From a Tertiary Hospital in Eastern China. Front Microbiol. 2018;9:3341. doi: 10.3389/fmicb.2018.03341. eCollection 2018. PubMed PMID: 30697205; PubMed Central PMCID: PMC6340961.
  9. Eilertson B, Chen L, Li A, Chavda KD, Chavda B, Kreiswirth BN. CG258 Klebsiella pneumoniae isolates without β-lactam resistance at the onset of the carbapenem-resistant Enterobacteriaceae epidemic in New York City. J Antimicrob Chemother. 2019 Jan 1;74(1):17-21. doi: 10.1093/jac/dky394. PubMed PMID: 30272172; PubMed Central PMCID: PMC6293082.
  10. Nygaard TK, Borgogna TR, Sward EW, Guerra FE, Dankoff JG, Collins MM, Pallister KB, Chen L, Kreiswirth BN, Voyich JM. Aspartic Acid Residue 51 of SaeR Is Essential for Staphylococcus aureus Virulence. Front Microbiol. 2018;9:3085. doi: 10.3389/fmicb.2018.03085. eCollection 2018. PubMed PMID: 30619166; PubMed Central PMCID: PMC6302044.
  11. Daniels JB, Chen L, Grooters SV, Mollenkopf DF, Mathys DA, Pancholi P, Kreiswirth BN, Wittum TE. Enterobacter cloacae Complex Sequence Type 171 Isolates Expressing KPC-4 Carbapenemase Recovered from Canine Patients in Ohio. Antimicrob Agents Chemother. 2018 Dec;62(12). doi: 10.1128/AAC.01161-18. Print 2018 Dec. PubMed PMID: 30249699; PubMed Central PMCID: PMC6256759.
  12. Satlin MJ, Chavda KD, Baker TM, Chen L, Shashkina E, Soave R, Small CB, Jacobs SE, Shore TB, van Besien K, Westblade LF, Schuetz AN, Fowler VG Jr, Jenkins SG, Walsh TJ, Kreiswirth BN. Colonization With Levofloxacin-resistant Extended-spectrum β-Lactamase-producing Enterobacteriaceae and Risk of Bacteremia in Hematopoietic Stem Cell Transplant Recipients. Clin Infect Dis. 2018 Nov 13;67(11):1720-1728. doi: 10.1093/cid/ciy363. PubMed PMID: 29701766; PubMed Central PMCID: PMC6233682.
  13. Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA. Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol. 2018 Nov;3(11):1327. doi: 10.1038/s41564-018-0281-9. PubMed PMID: 30327492.
  14. Chavda B, Lv J, Hou M, Chavda KD, Kreiswirth BN, Feng Y, Chen L, Yu F. Coidentification of mcr-4.3 and blaNDM-1 in a Clinical Enterobacter cloacae Isolate from China. Antimicrob Agents Chemother. 2018 Oct;62(10). doi: 10.1128/AAC.00649-18. Print 2018 Oct. PubMed PMID: 30038043; PubMed Central PMCID: PMC6153785.
  15. Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA. Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol. 2018 Oct;3(10):1099-1108. doi: 10.1038/s41564-018-0245-0. Epub 2018 Sep 17. PubMed PMID: 30224802; PubMed Central PMCID: PMC6158078.
  16. Yu F, Lv J, Niu S, Du H, Tang YW, Pitout JDD, Bonomo RA, Kreiswirth BN, Chen LMultiplex PCR Analysis for Rapid Detection of Klebsiella pneumoniae Carbapenem-Resistant (Sequence Type 258 [ST258] and ST11) and Hypervirulent (ST23, ST65, ST86, and ST375) Strains. J Clin Microbiol. 2018 Sep;56(9). doi: 10.1128/JCM.00731-18. Print 2018 Sep. PubMed PMID: 29925644; PubMed Central PMCID: PMC6113471.
  17. Yu F, Lv J, Niu S, Du H, Tang YW, Bonomo RA, Kreiswirth BN, Chen LIn Vitro Activity of Ceftazidime-Avibactam against Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae Isolates. Antimicrob Agents Chemother. 2018 Aug;62(8). doi: 10.1128/AAC.01031-18. Print 2018 Aug. PubMed PMID: 29891605; PubMed Central PMCID: PMC6105775.
  18. Mittal J, Szymczak WA, Guo Y, Levi MH, Chen L, Kreiswirth BN, Riska PF, Nori P. Two for the price of one: emerging carbapenemases in a returning traveller to New York City. BMJ Case Rep. 2018 Jul 18;2018. doi: 10.1136/bcr-2018-225440. PubMed PMID: 30021742.
  19. Bulman ZP, Zhao M, Satlin MJ, Chen L, Kreiswirth BN, Walsh TJ, Nation RL, Li J, Tsuji BT. Polymyxin B and fosfomycin thwart KPC-producing Klebsiella pneumoniae in the hollow-fibre infection model. Int J Antimicrob Agents. 2018 Jul;52(1):114-118. doi: 10.1016/j.ijantimicag.2018.02.010. Epub 2018 Feb 24. PubMed PMID: 29486233.
  20. Peirano G, Matsumura Y, Adams MD, Bradford P, Motyl M, Chen L, Kreiswirth BN, Pitout JDD. Genomic Epidemiology of Global Carbapenemase-Producing Enterobacter spp., 2008-2014. Emerg Infect Dis. 2018 Jun;24(6):1010-1019. doi: 10.3201/eid2406.171648. PubMed PMID: 29774858; PubMed Central PMCID: PMC6004858.
  21. Shields RK, Nguyen MH, Chen L, Press EG, Kreiswirth BN, Clancy CJ. Pneumonia and Renal Replacement Therapy Are Risk Factors for Ceftazidime-Avibactam Treatment Failures and Resistance among Patients with Carbapenem-Resistant Enterobacteriaceae Infections. Antimicrob Agents Chemother. 2018 May;62(5). doi: 10.1128/AAC.02497-17. Print 2018 May. PubMed PMID: 29507064; PubMed Central PMCID: PMC5923134.
  22. Huang B, He Y, Ma X, Cai R, Zeng J, Lu Y, Zhang W, Lan K, E S, Tang YW, Kreiswirth BN, Chen C, Chen LPromoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital. Antimicrob Agents Chemother. 2018 May;62(5). doi: 10.1128/AAC.00018-18. Print 2018 May. PubMed PMID: 29463536; PubMed Central PMCID: PMC5923141.
  23. Kanwar A, Marshall SH, Perez F, Tomas M, Jacobs MR, Hujer AM, Domitrovic TN, Rudin SD, Rojas LJ, Kreiswirth BN, Chen L, Quinones-Mateu M, van Duin D, Bonomo RA. Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniaeOpen Forum Infect Dis. 2018 Apr;5(4):ofy054. doi: 10.1093/ofid/ofy054. eCollection 2018 Apr. PubMed PMID: 30014001; PubMed Central PMCID: PMC5913667.
  24. Kobayashi SD, Porter AR, Freedman B, Pandey R, Chen L, Kreiswirth BN, DeLeo FR. Antibody-Mediated Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils. MBio. 2018 Mar 13;9(2). doi: 10.1128/mBio.00297-18. PubMed PMID: 29535199; PubMed Central PMCID: PMC5850326.
  25. Shields RK, Clancy CJ, Pasculle AW, Press EG, Haidar G, Hao B, Chen L, Kreiswirth BN, Nguyen MH. Verification of Ceftazidime-Avibactam and Ceftolozane-Tazobactam Susceptibility Testing Methods against Carbapenem-Resistant Enterobacteriaceae and Pseudomonas aeruginosa. J Clin Microbiol. 2018 Feb;56(2). doi: 10.1128/JCM.01093-17. Print 2018 Feb. PubMed PMID: 29167294; PubMed Central PMCID: PMC5786715.
  26. Chen L, Kreiswirth BN. Convergence of carbapenem-resistance and hypervirulence in Klebsiella pneumoniae. Lancet Infect Dis. 2018 Jan;18(1):2-3. doi: 10.1016/S1473-3099(17)30517-0. Epub 2017 Aug 29. PubMed PMID: 28864028.
  27. Zhang H, Miao M, Yan J, Wang M, Tang YW, Kreiswirth BN, Zhang X, Chen L, Du H. Expression characteristics of the plasmid-borne mcr-1 colistin resistance gene. Oncotarget. 2017 Dec 8;8(64):107596-107602. doi: 10.18632/oncotarget.22538. eCollection 2017 Dec 8. PubMed PMID: 29296190; PubMed Central PMCID: PMC5746092.
  28. MacVane SH, Pandey R, Steed LL, Kreiswirth BN, Chen LEmergence of Ceftolozane-Tazobactam-Resistant Pseudomonas aeruginosa during Treatment Is Mediated by a Single AmpC Structural Mutation. Antimicrob Agents Chemother. 2017 Dec;61(12). doi: 10.1128/AAC.01183-17. Print 2017 Dec. PubMed PMID: 28947473; PubMed Central PMCID: PMC5700322.
  29. Chatterjee SS, Chen L, Gilbert A, da Costa TM, Nair V, Datta SK, Kreiswirth BN, Chambers HF. PBP4 Mediates β-Lactam Resistance by Altered Function. Antimicrob Agents Chemother. 2017 Nov;61(11). doi: 10.1128/AAC.00932-17. Print 2017 Nov. PubMed PMID: 28807923; PubMed Central PMCID: PMC5655059.
  30. Al Laham N, Chavda KD, Cienfuegos-Gallet AV, Kreiswirth BN, Chen LGenomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine. Antimicrob Agents Chemother. 2017 Nov;61(11). doi: 10.1128/AAC.01499-17. Print 2017 Nov. PubMed PMID: 28848020; PubMed Central PMCID: PMC5655106.
  31. Haidar G, Clancy CJ, Chen L, Samanta P, Shields RK, Kreiswirth BN, Nguyen MH. Identifying Spectra of Activity and Therapeutic Niches for Ceftazidime-Avibactam and Imipenem-Relebactam against Carbapenem-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Sep;61(9). doi: 10.1128/AAC.00642-17. Print 2017 Sep. PubMed PMID: 28630202; PubMed Central PMCID: PMC5571343.
  32. Shields RK, Nguyen MH, Chen L, Press EG, Potoski BA, Marini RV, Doi Y, Kreiswirth BN, Clancy CJ. Ceftazidime-Avibactam Is Superior to Other Treatment Regimens against Carbapenem-Resistant Klebsiella pneumoniae Bacteremia. Antimicrob Agents Chemother. 2017 Aug;61(8). doi: 10.1128/AAC.00883-17. Print 2017 Aug. PubMed PMID: 28559250; PubMed Central PMCID: PMC5527595.
  33. Cienfuegos-Gallet AV, Chen L, Kreiswirth BN, Jiménez JN. Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae Mediated by Chromosomal Integration of Plasmid DNA. Antimicrob Agents Chemother. 2017 Aug;61(8). doi: 10.1128/AAC.00404-17. Print 2017 Aug. PubMed PMID: 28507118; PubMed Central PMCID: PMC5527652.
  34. Matsumura Y, Peirano G, Devinney R, Bradford PA, Motyl MR, Adams MD, Chen L, Kreiswirth B, Pitout JDD. Genomic epidemiology of global VIM-producing Enterobacteriaceae. J Antimicrob Chemother. 2017 Aug 1;72(8):2249-2258. doi: 10.1093/jac/dkx148. PubMed PMID: 28520983; PubMed Central PMCID: PMC5890710.
  35. Bulman ZP, Chen L, Walsh TJ, Satlin MJ, Qian Y, Bulitta JB, Peloquin CA, Holden PN, Nation RL, Li J, Kreiswirth BN, Tsuji BT. Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era. MBio. 2017 Jul 25;8(4). doi: 10.1128/mBio.00540-17. PubMed PMID: 28743810; PubMed Central PMCID: PMC5527306.
  36. Shields RK, Nguyen MH, Press EG, Chen L, Kreiswirth BN, Clancy CJ. Emergence of Ceftazidime-Avibactam Resistance and Restoration of Carbapenem Susceptibility in Klebsiella pneumoniae Carbapenemase-Producing K pneumoniae: A Case Report and Review of Literature. Open Forum Infect Dis. 2017 Summer;4(3):ofx101. doi: 10.1093/ofid/ofx101. eCollection 2017 Summer. PubMed PMID: 28685153; PubMed Central PMCID: PMC5493938.
  37. Evans SR, Hujer AM, Jiang H, Hill CB, Hujer KM, Mediavilla JR, Manca C, Tran TTT, Domitrovic TN, Higgins PG, Seifert H, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Sampath R, Hall T, Marzan C, Fowler VG Jr, Chambers HF, Bonomo RA. Correction for Evans et al., “Informing Antibiotic Treatment Decisions: Evaluating Rapid Molecular Diagnostics To Identify Susceptibility and Resistance to Carbapenems against Acinetobacter spp. in PRIMERS III”. J Clin Microbiol. 2017 Jun;55(6):1970. doi: 10.1128/JCM.00525-17. PubMed PMID: 28536161; PubMed Central PMCID: PMC5442558.
  38. Zhan L, Wang S, Guo Y, Jin Y, Duan J, Hao Z, Lv J, Qi X, Hu L, Chen L, Kreiswirth BN, Zhang R, Pan J, Wang L, Yu F. Outbreak by Hypermucoviscous Klebsiella pneumoniae ST11 Isolates with Carbapenem Resistance in a Tertiary Hospital in China. Front Cell Infect Microbiol. 2017;7:182. doi: 10.3389/fcimb.2017.00182. eCollection 2017. PubMed PMID: 28560183; PubMed Central PMCID: PMC5432538.
  39. Shields RK, Nguyen MH, Press EG, Chen L, Kreiswirth BN, Clancy CJ. In Vitro Selection of Meropenem Resistance among Ceftazidime-Avibactam-Resistant, Meropenem-Susceptible Klebsiella pneumoniae Isolates with Variant KPC-3 Carbapenemases. Antimicrob Agents Chemother. 2017 May;61(5). doi: 10.1128/AAC.00079-17. Print 2017 May. PubMed PMID: 28242667; PubMed Central PMCID: PMC5404588.
  40. Satlin MJ, Chen L, Patel G, Gomez-Simmonds A, Weston G, Kim AC, Seo SK, Rosenthal ME, Sperber SJ, Jenkins SG, Hamula CL, Uhlemann AC, Levi MH, Fries BC, Tang YW, Juretschko S, Rojtman AD, Hong T, Mathema B, Jacobs MR, Walsh TJ, Bonomo RA, Kreiswirth BN. Multicenter Clinical and Molecular Epidemiological Analysis of Bacteremia Due to Carbapenem-Resistant Enterobacteriaceae (CRE) in the CRE Epicenter of the United States. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02349-16. Print 2017 Apr. PubMed PMID: 28167547; PubMed Central PMCID: PMC5365653.
  41. Eilertson B, Chen L, Chavda KD, Kreiswirth BN. Genomic Characterization of Two KPC-Producing Klebsiella Isolates Collected in 1997 in New York City. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02458-16. Print 2017 Apr. PubMed PMID: 28167551; PubMed Central PMCID: PMC5365676.
  42. DeLeo FR, Kobayashi SD, Porter AR, Freedman B, Dorward DW, Chen L, Kreiswirth BN. Survival of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 in Human Blood. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02533-16. Print 2017 Apr. PubMed PMID: 28115349; PubMed Central PMCID: PMC5365663.
  43. Matsumura Y, Peirano G, Motyl MR, Adams MD, Chen L, Kreiswirth B, DeVinney R, Pitout JD. Global Molecular Epidemiology of IMP-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02729-16. Print 2017 Apr. PubMed PMID: 28167555; PubMed Central PMCID: PMC5365671.
  44. Bulman ZP, Satlin MJ, Chen L, Kreiswirth BN, Shin BS, Walsh TJ, Holden PN, Forrest A, Nation RL, Li J, Tsuji BT. New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02023-16. Print 2017 Apr. PubMed PMID: 28167549; PubMed Central PMCID: PMC5365650.
  45. Yu F, Wang S, Lv J, Qi X, Guo Y, Tang YW, Kreiswirth BN, Wang L, Chen LCoexistence of OXA-48-Producing Klebsiella pneumoniae and Escherichia coli in a Hospitalized Patient Who Returned from Europe to China. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02580-16. Print 2017 Apr. PubMed PMID: 28115343; PubMed Central PMCID: PMC5365688.
  46. Peirano G, Bradford PA, Kazmierczak KM, Chen L, Kreiswirth BN, Pitout JD. Importance of Clonal Complex 258 and IncFK2-like Plasmids among a Global Collection of Klebsiella pneumoniae with blaKPC. Antimicrob Agents Chemother. 2017 Apr;61(4). doi: 10.1128/AAC.02610-16. Print 2017 Apr. PubMed PMID: 28167556; PubMed Central PMCID: PMC5365689.
  47. Wang M, Zheng Y, Mediavilla JR, Chen L, Kreiswirth BN, Song Y, Yang R, Du H. Hospital Dissemination of tst-1-Positive Clonal Complex 5 (CC5) Methicillin-Resistant Staphylococcus aureusFront Cell Infect Microbiol. 2017;7:101. doi: 10.3389/fcimb.2017.00101. eCollection 2017. PubMed PMID: 28409124; PubMed Central PMCID: PMC5374150.
  48. Simpson G, Zimmerman R, Shashkina E, Chen L, Richard M, Bradford CM, Dragoo GA, Saiers RL, Peloquin CA, Daley CL, Planet P, Narachenia A, Mathema B, Kreiswirth BN. Mycobacterium tuberculosis Infection among Asian Elephants in Captivity. Emerg Infect Dis. 2017 Mar;23(3):513-516. doi: 10.3201/eid2303.160726. PubMed PMID: 28221115; PubMed Central PMCID: PMC5382730.
  49. Shields RK, Chen L, Cheng S, Chavda KD, Press EG, Snyder A, Pandey R, Doi Y, Kreiswirth BN, Nguyen MH, Clancy CJ. Emergence of Ceftazidime-Avibactam Resistance Due to Plasmid-Borne blaKPC-3 Mutations during Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections. Antimicrob Agents Chemother. 2017 Mar;61(3). doi: 10.1128/AAC.02097-16. Print 2017 Mar. PubMed PMID: 28031201; PubMed Central PMCID: PMC5328542.
  50. Planet PJ, Narechania A, Chen L, Mathema B, Boundy S, Archer G, Kreiswirth B. Architecture of a Species: Phylogenomics of Staphylococcus aureus. Trends Microbiol. 2017 Feb;25(2):153-166. doi: 10.1016/j.tim.2016.09.009. Epub 2016 Oct 14. Review. PubMed PMID: 27751626.
  1. Guo Y, Wang S, Zhan L, Jin Y, Duan J, Hao Z, Lv J, Qi X, Chen L, Kreiswirth BN, Wang L, Yu F. Microbiological and Clinical Characteristics of Hypermucoviscous Klebsiella pneumoniae Isolates Associated with Invasive Infections in China. Front Cell Infect Microbiol. 2017;7:24. doi: 10.3389/fcimb.2017.00024. eCollection 2017. PubMed PMID: 28203549; PubMed Central PMCID: PMC5286779.
  2. Evans SR, Hujer AM, Jiang H, Hill CB, Hujer KM, Mediavilla JR, Manca C, Tran TT, Domitrovic TN, Higgins PG, Seifert H, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Sampath R, Hall T, Marzan C, Fowler VG Jr, Chambers HF, Bonomo RA. Informing Antibiotic Treatment Decisions: Evaluating Rapid Molecular Diagnostics To Identify Susceptibility and Resistance to Carbapenems against Acinetobacter spp. in PRIMERS III. J Clin Microbiol. 2017 Jan;55(1):134-144. doi: 10.1128/JCM.01524-16. Print 2017 Jan. PubMed PMID: 27795336; PubMed Central PMCID: PMC5228224.
  3. Shields RK, Potoski BA, Haidar G, Hao B, Doi Y, Chen L, Press EG, Kreiswirth BN, Clancy CJ, Nguyen MH. Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections. Clin Infect Dis. 2016 Dec 15;63(12):1615-1618. doi: 10.1093/cid/ciw636. Epub 2016 Sep 13. PubMed PMID: 27624958; PubMed Central PMCID: PMC5146720.
  4. Chavda KD, Chen L, Fouts DE, Sutton G, Brinkac L, Jenkins SG, Bonomo RA, Adams MD, Kreiswirth BN. Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms. 2016 Dec 13;7(6). doi: 10.1128/mBio.02093-16. PubMed PMID: 27965456; PubMed Central PMCID: PMC5156309.
  5. Chavda KD, Satlin MJ, Chen L, Manca C, Jenkins SG, Walsh TJ, Kreiswirth BN. Evaluation of a Multiplex PCR Assay To Rapidly Detect Enterobacteriaceae with a Broad Range of β-Lactamases Directly from Perianal Swabs. Antimicrob Agents Chemother. 2016 Nov;60(11):6957-6961. doi: 10.1128/AAC.01458-16. Print 2016 Nov. PubMed PMID: 27600053; PubMed Central PMCID: PMC5075117.
  6. Li L, Cheung A, Bayer AS, Chen L, Abdelhady W, Kreiswirth BN, Yeaman MR, Xiong YQ. The Global Regulon sarA Regulates β-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections. J Infect Dis. 2016 Nov 1;214(9):1421-1429. doi: 10.1093/infdis/jiw386. Epub 2016 Aug 19. PubMed PMID: 27543672; PubMed Central PMCID: PMC5079373.
  7. Lv J, Qi X, Zhang D, Zheng Z, Chen Y, Guo Y, Wang S, Chen L, Kreiswirth BN, Tang YW, Chen Z, Hu L, Wang L, Yu F. First Report of Complete Sequence of a blaNDM-13-Harboring Plasmid from an Escherichia coli ST5138 Clinical Isolate. Front Cell Infect Microbiol. 2016;6:130. doi: 10.3389/fcimb.2016.00130. eCollection 2016. PubMed PMID: 27790412; PubMed Central PMCID: PMC5061728.
  8. Satlin MJ, Cohen N, Ma KC, Gedrimaite Z, Soave R, Askin G, Chen L, Kreiswirth BN, Walsh TJ, Seo SK. Bacteremia due to carbapenem-resistant Enterobacteriaceae in neutropenic patients with hematologic malignancies. J Infect. 2016 Oct;73(4):336-45. doi: 10.1016/j.jinf.2016.07.002. Epub 2016 Jul 9. PubMed PMID: 27404978; PubMed Central PMCID: PMC5026910.
  9. Evans SR, Pennello G, Pantoja-Galicia N, Jiang H, Hujer AM, Hujer KM, Manca C, Hill C, Jacobs MR, Chen L, Patel R, Kreiswirth BN, Bonomo RA. Benefit-risk Evaluation for Diagnostics: A Framework (BED-FRAME). Clin Infect Dis. 2016 Sep 15;63(6):812-7. doi: 10.1093/cid/ciw329. Epub 2016 May 18. PubMed PMID: 27193750; PubMed Central PMCID: PMC4996133.
  10. Lynch T, Chen L, Peirano G, Gregson DB, Church DL, Conly J, Kreiswirth BN, Pitout JD. Molecular Evolution of a Klebsiella pneumoniae ST278 Isolate Harboring blaNDM-7 and Involved in Nosocomial Transmission. J Infect Dis. 2016 Sep 1;214(5):798-806. doi: 10.1093/infdis/jiw240. Epub 2016 Jun 9. PubMed PMID: 27284091; PubMed Central PMCID: PMC4978375.
  11. Mediavilla JR, Patrawalla A, Chen L, Chavda KD, Mathema B, Vinnard C, Dever LL, Kreiswirth BN. Colistin- and Carbapenem-Resistant Escherichia coli Harboring mcr-1 and blaNDM-5, Causing a Complicated Urinary Tract Infection in a Patient from the United States. 2016 Aug 30;7(4). doi: 10.1128/mBio.01191-16. PubMed PMID: 27578755; PubMed Central PMCID: PMC4999550.
  12. Yu H, Qu F, Shan B, Huang B, Jia W, Chen C, Li A, Miao M, Zhang X, Bao C, Xu Y, Chavda KD, Tang YW, Kreiswirth BN, Du H, Chen LDetection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China. Antimicrob Agents Chemother. 2016 Aug;60(8):5033-5. doi: 10.1128/AAC.00440-16. Print 2016 Aug. PubMed PMID: 27216058; PubMed Central PMCID: PMC4958199.
  13. Li A, Yang Y, Miao M, Chavda KD, Mediavilla JR, Xie X, Feng P, Tang YW, Kreiswirth BN, Chen L, Du H. Complete Sequences of mcr-1-Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae. Antimicrob Agents Chemother. 2016 Jul;60(7):4351-4. doi: 10.1128/AAC.00550-16. Print 2016 Jul. PubMed PMID: 27090180; PubMed Central PMCID: PMC4914624.
  14. Chavda KD, Chen L, Jacobs MR, Bonomo RA, Kreiswirth BN. Molecular Diversity and Plasmid Analysis of KPC-Producing Escherichia coli. Antimicrob Agents Chemother. 2016 Jul;60(7):4073-81. doi: 10.1128/AAC.00452-16. Print 2016 Jul. PubMed PMID: 27114279; PubMed Central PMCID: PMC4914655.
  15. Kobayashi SD, Porter AR, Dorward DW, Brinkworth AJ, Chen L, Kreiswirth BN, DeLeo FR. Phagocytosis and Killing of Carbapenem-Resistant ST258 Klebsiella pneumoniae by Human Neutrophils. J Infect Dis. 2016 May 15;213(10):1615-22. doi: 10.1093/infdis/jiw001. Epub 2016 Jan 14. PubMed PMID: 26768252; PubMed Central PMCID: PMC4837910.
  16. Prasad N, Labaze G, Kopacz J, Chwa S, Platis D, Pan CX, Russo D, LaBombardi VJ, Osorio G, Pollack S, Kreiswirth BN, Chen L, Urban C, Segal-Maurer S. Asymptomatic rectal colonization with carbapenem-resistant Enterobacteriaceae and Clostridium difficile among residents of a long-term care facility in New York City. Am J Infect Control. 2016 May 1;44(5):525-32. doi: 10.1016/j.ajic.2015.11.021. Epub 2016 Jan 18. PubMed PMID: 26796684.
  17. Buehrle DJ, Shields RK, Chen L, Hao B, Press EG, Alkrouk A, Potoski BA, Kreiswirth BN, Clancy CJ, Nguyen MH. Evaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates. Antimicrob Agents Chemother. 2016 May;60(5):3227-31. doi: 10.1128/AAC.02969-15. Print 2016 May. PubMed PMID: 26976862; PubMed Central PMCID: PMC4862525.
  18. Xie X, Zhang H, Zheng Y, Li A, Wang M, Zhou H, Zhu X, Schneider Z, Chen L, Kreiswirth BN, Du H. RpoE is a Putative Antibiotic Resistance Regulator of Salmonella enteric Serovar Typhi. Curr Microbiol. 2016 Apr;72(4):457-64. doi: 10.1007/s00284-015-0983-7. Epub 2016 Jan 7. PubMed PMID: 26742769.
  19. Du H, Chen L, Chavda KD, Pandey R, Zhang H, Xie X, Tang YW, Kreiswirth BN. Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases. Antimicrob Agents Chemother. 2016 Apr;60(4):2519-23. doi: 10.1128/AAC.03053-15. Print 2016 Apr. PubMed PMID: 26787700; PubMed Central PMCID: PMC4808189.
  20. Du H, Chen L, Tang YW, Kreiswirth BN. Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae. Lancet Infect Dis. 2016 Mar;16(3):287-8. doi: 10.1016/S1473-3099(16)00056-6. Epub 2016 Feb 1. PubMed PMID: 26842776.
  21. Evans SR, Hujer AM, Jiang H, Hujer KM, Hall T, Marzan C, Jacobs MR, Sampath R, Ecker DJ, Manca C, Chavda K, Zhang P, Fernandez H, Chen L, Mediavilla JR, Hill CB, Perez F, Caliendo AM, Fowler VG Jr, Chambers HF, Kreiswirth BN, Bonomo RA. Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II. Clin Infect Dis. 2016 Jan 15;62(2):181-9. doi: 10.1093/cid/civ837. Epub 2015 Sep 25. PubMed PMID: 26409063; PubMed Central PMCID: PMC4690483.

Ocampo AM, Chen L, Cienfuegos AV, Roncancio G, Chavda KD, Kreiswirth BN, Jiménez JN. A Two-Year Surveillance in Five Colombian Tertiary Care Hospitals Reveals High Frequency of Non-CG258 Clones of Carbapenem-Resistant Klebsiella pneumoniae with Distinct Clinical Characteristics. Antimicrob Agents Chemother. 2016 Jan;60(1):332-42. doi: 10.1128/AAC.01775-15. Print 2016 Jan. PubMed PMID: 26503660; PubMed Central PMCID: PMC4704171.

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